Developmental Neuronal Plasticity

Molecular pathways underlying activity-dependent dendrite growth

Using single-cell electroporation for controlling gene expression in individual neurons within the intact developing brain we are dissecting the molecular pathways mediating developmental brain plasticity. Our findings that the kinase PKMz regulates dendritic arbor growth suggests that developmental morphological plasticity employs the same molecular mechanisms that underlie synapse plasticity, learning and memory in the mature brain